Unlike olfactory system receptor cells, individual
taste receptor cells express multiple
T2R receptors. Up to ten T2R probes hybridize to
only a few cells, shown darkened (1). Doublelabel
fluorescent in-situ hybridization shows
that different receptor genes (2, T2R-3 in green
and T2R-7 in red, 3) are expressed in the same
taste receptor cell. The T2Rs confer high sensitivity
for bitter substances at low concentrations
but do not distinguish between them.
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